Answer: Micronized progesterone is a very fine powder of progesterone crystals, which are too fine to notice on the skin. The other form of progesterone is progesterone dissolved in Vitamin E, which only a few brands sell. It is believed to greatly help absorption. Applying a micronized progesterone will smear this ultra-fine powder evenly over your skin, but because the crystals are made up of big clumps of progesterone molecules, they don't absorb quickly as they molecules must first split off of these crystals. But when you apply progesterone dissolved in Vitamin E to your skin, the molecules are ready to be absorbed.